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Medical Oncology

Assessment of the acutely ill patient with malignancy |Practice of common symptom control problems |Oncological emergencies : hypercalcaemia | superior vena caval obstruction | spinal cord compression | cardiac tamponade | neutropenic infection | Cancer staging |Solid tumours :lymphoma |Breast Ca | Ovarian Ca | Testicular Ca | Prostate Ca | Lung cancer |Principles of anticancer therapies: endocrine and cytotoxic chemotherapy | radiation therapy | palliative care | assessment and management of toxicity | assessment of response to therapy | adjuvant therapy | neo-adjuvant therapy | palliative therapy | curative therapy| cancers that can be cured by primary chemotherapy: including testicular cancers and lymphomas |Knowledge of cancers in which adjuvant or neo-adjuvant chemotherapy may enhance the outcomes of local treatment: including breast, head and neck, lung, colon and ovarian cancers and osteosarcoma |Knowledge of those common cancers that can be palliated by non surgical cancer therapies: including breast cancer, lung cancer, colorectal cancer, and prostate cancer | of the paraneoplastic syndromes | Principles of palliative therapies |Understanding of the genetic pathophysiology of common malignancies |Mechanism of action and toxicities of various classes of cytotoxic drugs |Principles of clinical drug development and randomised clinical trials |Practice of pain control | Counselling of patients

 

Assessment of the acutely ill patient with malignancy.

Practice of common symptom control problems: pain, dyspnoea, nausea and vomiting, diarrhoea, constipation and bowel obstruction.

Exam Question

2002 paper one question 63 Pain control and morphine conversion principles

2005 paper one question 34The most common mechanism for malignant ascites is obstruction of abdominal lymphatics.

Management of oncological emergencies due to disease or therapy: including hypercalcaemia; superior vena caval obstruction; spinal cord compression; cardiac tamponade; neutropenic infection.

Exam questions

2005 paper one question 63 Hyperkalemia, Hyperphosphatemia and Hypocalcemia are the electrolyte disturbances in tumour lysis syndrome

Principles of cancer staging.

Exam Questions

2003 paper two question 80 Use of EUS in staging oesophageal Cancer Repeat Question 2004 paper two question 87

References:

Esophageal Cancer PC Enzinger and RJ Mayer NEJM 2003;349:2241-52

Principles of the management of solid tumours with an emphasis on lymphoma,

cancer of the breast,

exam questions

2002 paper two question 48 The use of radiotherapy in the treatment of breast cancer

2003 paper one question 54 Treatment of hormone-responsive metastatic breast cancer

Repeat Question
2003 paper two question 2 Popular Question about the risk assessment of breast cancer in family with consideration for family history and BRCA1 and BRCA2 genes repeat 2004 paper two question 88

2003 paper two question 19 Contraindication to the use of SERM

2004 paper one question 39 HER-2 overexpression effects treatment decisions in metastatic breast cancer

2004 paper one question 67 Long-term hormone replacement therapy (>5 years) in postmenopausal women results in the greatest increase in absolute risk of cancer of the Breast

2005 paper two question 46 Treatment of human epidermal growth factor receptor 2 protein (Her2) is with trastuzumab (herceptin) but not letrozole

Reference

Local therapy and survival in breast Cancer
Rinaa S. Punglia, M.D., M.P.H., Monica Morrow, M.D., Eric P. Winer, M.D., and Jay R. Harris, M.D.
NEJM Vol 356 pp 2399-2405 June 7 2007 No. 23

BMJ ABC of Breast Disease

CLINICAL REVIEW:
J R C Sainsbury, T J Anderson, and D A L Morgan
ABC of breast diseases: Breast cancer
BMJ, Sep 2000; 321: 745 - 750

CLINICAL REVIEW:
R W Blamey, A R M Wilson, and J Patnick
ABC of breast diseases: Screening for breast cancer
BMJ, Sep 2000; 321: 689 - 693

CLINICAL REVIEW:
K McPherson, C M Steel, and J M Dixon
ABC of breast diseases: Breast cancerepidemiology, risk factors, and genetics
BMJ, Sep 2000; 321: 624 - 628 ;

Medical treatment of early breast cancer. IV:
neoadjuvant treatment
Ian Smith and Susan Chua

Follow-up of Patients with Early Breast Cancer
D. F. Hayes N Engl J Med 2007;356:2505-13.

ovary,

Exam Questions

2003 paper two question 20 Ovarian Cancer and cerebellar syndrome - paraneoplastic syndrome Question repeated 2002 paper two question 56

 

References

Ovarian cancer and HRT in the Million Woman Study” Lancet 2007; 369:1703-10

Symposium on Solid Tumors
Current Management Strategies for Ovarian Cancer
Mayo Clin Proc June 2007 82(6) 751-770

testis

Exam questions

2002 paper two question 23 The use of tumour markers in young man with large mediastinal mass

2004 paper two question 12 post resection management of a stage I non-seminomatous testicular germ cell tumour with no vascular invasion (low risk) is Regular surveillance

prostate,

lung cancer.

Exam Questions

2002 paper two question 37 Treatment for lung CA

2005 paper two question 85 mediastinal mass in 50 year old most likely lung CA

Principles of anticancer therapies: endocrine and cytotoxic chemotherapy, radiation therapy and palliative care. Principles of monitoring of patients receiving anti-cancer treatments: assessment and management of toxicity; assessment of response to therapy.Concepts of 'adjuvant', 'neo-adjuvant', 'palliative' and 'curative' therapies for malignancy.

Principles of clinical drug development and randomised clinical trials.

exam questions

2002 paper one question 25 Drug Trials objectives of each phase

2002 paper one question 65 Survival curve

2002 paper two question 10 Consent in clinical trial

 

2003 paper two question 3 Use of Karnofsy performance scale in determining choice of treatment and survival repeat question 2004 paper two question 72

2003 paper one question 11 principle of surgical tumour debulking prior to chemo

2003 paper one question 54 Treatment of hormone-responsive metastatic breast cancer

 

References

Metastasis: recent discoveries and novel treatment strategies
The LancetVolume 369, Issue 957419 May 2007-25 May 2007Pages 1742-1757
Suzanne A Eccles and Danny R Welch

Knowledge of cancers that can be cured by primary chemotherapy: including testicular cancers and lymphomas.

Knowledge of cancers in which adjuvant or neo-adjuvant chemotherapy may enhance the outcomes of local treatment: including breast,

head and neck,

lung, colon and ovarian cancers and

osteosarcoma.

exam questions

2004 paper two question 56 diagnosing Osteogenic sarcoma in young woman on xray


Knowledge of those common cancers that can be palliated by non surgical cancer therapies: including breast cancer, lung cancer,

colorectal cancer,

see Gastroenterology: colorectal cancer

exam question

2003 paper one question 28 use of CAE in colorectal cancer management repeat question 2002 paper one 53

2004 paper one question 43 Polyp type and risk of developing colorectal repeated 2003 paper one question 62

2003 paper two question 18Hereditary non-polyposis colon cancer (HNPCC or Lynch syndrome) - associated malignancies cancer

2004 paper two question 40 Investigating change in bowel habit

reference

and prostate cancer.

Knowledge of the paraneoplastic syndromes associated with cancer.

exam questions

2003 paper two question 20 Ovarian Cancer and cerebellar syndrome - paraneoplastic syndrome Question repeated 2002 paper two question 56

references

Paraneoplastic Syndromes Involving the Nervous system
Darnell RB, Posner JB
NEJM 349: 1543, October 16, 2003 Review Article


Principles of palliative therapies: the aims of treatment and the concept of balance between efficacy and toxicity/quality of life.

Exam Questions

2003 paper two question 9 Influences in suicidal ideation in the context of pall care patient

2003 paper two question 71 Causes of acute confusional state in pallative patient with metastatic breast Ca

References

Understanding of the genetic pathophysiology of common malignancies: including breast, colon, and stomach cancer, and leukaemia.

Exam Questions

2003 paper one question 23 Mutation in a proto-oncogene is a missence mutaion

2003 paper two question 73 Expression of RET proto-oncogene in (MEN) type 2 and Medullary Thyroid Carcinoma

References

Mechanism of action and toxicities of various classes of cytotoxic drugs.

2002 paper two question 11 anthracycline-related cardiac toxicity

2003 paper one question 67 action on cancer cells of chemotherapeutic agents with first order kinetics

2003 paper two question 28 Complication of chemotherapy agents - ARDS with all-trans retinoic acid question repeated 2005 paper two question 61

2003 paper two question 55 Drug rash induced by Capcitabine

2003 paper two question 68 Prolonged granulocytopenia and risk of fungal infection with chemotherapy

2004 paper one question 25Cisplatin is classically the most emetogenic drug

2005 paper two question 10 In addition to a 5HT3-receptor antagonist, the most effective agent used to prevent acute chemotherapy-induced nausea with a highly emetogenic drug (i.e. cisplatin) is: dexamethasone

2005 paper two question 28 lower extremity weakness is a clinical sign of steroid myopathy in patient treated for large cell lung ca


Practice of pain control: knowledge of the pharmacological and non pharmacological modalities available.

Counselling of patients on the practicalities of administration and toxicities induced by chemotherapy and radiotherapy.

Psyciatry and oncology

exam question

2002 paper two question 88 Suicide ideation in cancer patients